Se trata de la Sputnik V que además es eficiente con una sola dosis.
![Comprobaron una vacuna que no produce trombosis 1 informe vacuna 2](https://i0.wp.com/diariolujan.ar/wp-content/uploads/2021/04/informe-vacuna-2.jpg?resize=810%2C456&ssl=1)
Desde el Centro Gamaleya aseguraron que la dosis es «un producto altamente purificado que pasa por un control obligatorio que incluye el análisis de la presencia de ADN libre”. Además, un informe del CONICET mostró que el 94% de las personas que recibieron una sola dosis de la vacuna producen anticuerpos específicos.
La Sputnik V se produce con la línea celular HEK293, que se utilizó de forma segura para productos biotecnológicos. Un análisis de los eventos adversos durante los ensayos clínicos y en el transcurso de las inmunizaciones masivas con la vacuna Sputnik V contra el coronavirus, demostró que «no hubo casos de trombosis del seno venoso cerebral» (CVST), explicaron desde el Centro Gamaleya.
Además, según un informe del CONICET dado a conocer el martes 13 de abril, la Sputnik V produce una alta respuesta inmune aún con una sola dosis. Así lo revela el informe final de la primera etapa de un estudio, liderado por investigadores/as del CONICET y realizado bajo la coordinación del Ministerio de Salud de la Provincia de Buenos Aires. El trabajo mostró que el 94% de las personas que recibieron una sola dosis de la vacuna producen anticuerpos específicos.
«Estamos listos para compartir la tecnología de purificación con otros productores de vacunas para ayudarlos a minimizar el riesgo de efectos adversos», expresaron desde el Centro Gamaleya.
“Todas las vacunas basadas en la plataforma de vectores adenovirales son diferentes y no directamente comparables. En particular, la vacuna ChAdOx1-S de AstraZeneca usa adenovirus de chimpancé para administrar el antígeno, que consiste en proteína S combinada con la secuencia líder del activador del plasminógeno de tipo tisular”, explicaron desde el laboratorio ruso a través de un tuiteo realizado a través de su cuenta de la red social.
También agregaron que “la vacuna de Johnson & Johnson utiliza el serotipo de adenovirus humano Ad26 y proteína S de longitud completa estabilizada por mutaciones. Además, se produce utilizando la línea celular PER.C6 (células retinianas embrionarias), que no está ampliamente representada entre otros productos registrados”.
La vacuna Sputnik V “es de dos componentes en la que se utilizan los serotipos de adenovirus 5 y 26. No se usa un fragmento de activador de plasminógeno de tipo tisular y el inserto de antígeno es una proteína S de longitud completa sin modificar. La Sputnik V se produce con la línea celular HEK293, que se utilizó de forma segura durante mucho tiempo para la producción de productos biotecnológicos”.
Luego explicaron que “no hay razón para extrapolar los datos de seguridad de una vacuna a los datos de seguridad de otras”.
Y recordaron que “la calidad y seguridad de Sputnik V están, entre otras cosas, aseguradas por el hecho de que, a diferencia de otras vacunas, utiliza una tecnología de purificación de 4 etapas que incluye dos etapas de cromatografía y dos de filtración de flujo tangencial”. Esta tecnología ayuda a obtener un producto altamente purificado que pasa por un control obligatorio que incluye el análisis de la presencia de ADN libre.
Un estudio publicado en The New England Journal of Medicine, el 9 de abril de 2021, analiza que la causa de la trombosis en algunos pacientes vacunados con otras vacunas “podría ser una purificación insuficiente que conduce a la aparición de cantidades significativas de ADN libre”.
Y agregaron que “una purificación insuficiente o el uso de dosis muy altas de ADN / ARN diana puede resultar en una interacción adversa de los anticuerpos de un paciente que activan los trombocitos con elementos de la propia vacuna y / o ADN / ARN libre, que pueden formar un complejo con el factor PF4”.
Por último, aclararon que “el Centro Gamaleya está listo para compartir su tecnología de purificación con otros productores de vacunas para ayudarlos a minimizar el riesgo de efectos adversos durante la vacunación”.
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